Biosynthesis, bioactions and biomedical applications of the protectins: New leads in resolution pharmacology

DRA lecture held by Professor Trond Vidar Hansen, Department of Pharmacy, University of Oslo, Norway

Endogenous ω-3 polyunsaturated fatty acids (PUFAs) are enzymatically converted during inflammation-resolution processes to novel products named specialized pro-resolving mediators (SPMs). The SPMs promote clearance of bacteria and apoptotic cells, down regulate pro-inflammatory mediator production and stimulate the resolution of inflammation.1 Clinical trial development programs with SPMs are ongoing and SPMs have received attention as leads in drug discovery programs.

The LIPCHEM group has reported total synthesis, biosynthetic studies, medicinal chemistry projects and biological evaluations based on several SPMs.2

Chemical reaction

  1. Serhan, C. N. Nature 2014, 510, 92.
  2. See the LIPCHEM website at www.mn.uio.no/farmasi/english/research/groups/lipchem/ for more information and recent publications.

The lecture is organised on behalf of the graduate programme in pharmaceutical sciences, Drug Research Academy, by Professor Trond Ulven, Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen.

The DRA lecture is free of charge and open for attendance by all interested parties.