Computational Pharmaceutics - A New Paradigm of Drug Delivery

DRA lecture held by Associate Professor, Dr. Defang Ouyang, Institute of Chinese Medical Sciences/Faculty of Health Sciences, University of Macau, Taipa, Macau.

Google Scholar: https://scholar.google.com/citations?user=Dk11-RAAAAAJ&hl=en

In recent decades pharmaceutics and drug delivery have become increasingly critical in the pharmaceutical industry due to longer time, higher cost, and less productivity of new molecular entities (NMEs). However, current formulation development still relies on traditional trial-and-error experiments, which are time-consuming, costly, and unpredictable.

With the exponential growth of computing capability and algorithms, in recent ten years, a new discipline named “computational pharmaceutics” integrates with big data, artificial intelligence, and multi-scale modeling techniques into pharmaceutics, which offered great potential to shift the paradigm of drug delivery. Computational pharmaceutics can provide multi-scale lenses to pharmaceutical scientists, revealing physical, chemical, mathematical, and data-driven details ranging across pre-formulation studies, formulation screening, in vivo prediction in the human body, and precision medicine in the clinic. Several formulation cases in the area will be discussed, such as solid dispersion, microsphere and mRNA lipid nanoparticle.

The lecture is organised on behalf of the graduate programme in pharmaceutical sciences, Drug Research Academy, by Associate Professor Mingshi Yang, Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen.

The DRA lecture is free of charge and open for attendance by all interested parties. It is not necessary to pre-register.