Characterization and targeting of the cytotoxic species associated with neurodegenerative diseases

DRA symposium

This symposium will provide a detailed overview of the current approaches to characterize and identify the toxic species associated with the two most common neurodegenerative diseases as well as the strategies designed to identify new ligands that target them.

Prof Daniel Otzen and Prof Louise Serpell will lecture on the characterization and the targeting of the cytotoxicity of oligomeric and fibrillar structures formed by the proteins associated with Parkinson’s and Alzheimer’s Diseases, namely alpha-synuclein, amyloid beta and Tau. They will describe recent findings aimed not only at characterizing the toxic species formed by these three proteins but also the approaches designed to develop/identify ligands that target them. Moreover, they will describe state of the art biophysical and biological methods and techniques commonly used to characterize protein self-assembly into oligomers and fibrils and the mechanism of their toxicity to neuronal cells.

Programme

The symposium is organized on behalf of the graduate programme in pharmaceutical sciences, Drug Research Academy, by Associate Professor Céline Galvagnion, Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen.

The symposium is free of charge and open for attendance by all interested parties. It is not necessary to pre-register.