Trends in oral administration of macromolecules
DRA symposium
The oral delivery of macromolecular drugs is a crucial area of research in the pharmaceutical field. Macromolecules have immense therapeutic potential but face challenges in their oral administration. They are susceptible to enzymatic degradation in the gastrointestinal tract, as well as poor absorption, rendering them ineffective when administered orally. However, advancements in drug delivery technologies, such as formulation strategies and protective coatings, have enabled enhanced macromolecular stability and protection against enzymatic degradation and higher drug absorption. These approaches ensure a higher percentage of the administered dose reaches the target site, maximizing therapeutic efficacy. Oral delivery opens up opportunities for the treatment of a wide range of diseases, including diabetes, obesity, cancer, and cardiovascular disorders. Additionally, it holds the potential for personalized medicine and targeted therapy, minimizing off-target effects and enhancing therapeutic precision.
Programme
| 10:00 | Introduction Anette Müllertz, Professor, Department of Pharmacy, University of Copenhagen, Denmark |
| 10:05-10:50 |
Formulation Approaches for the Oral Administration of Peptides: Successes and Failures |
| 10:50-11:35 |
Oral delivery of RNA therapeutics Caitriona O’Driscoll, Professor and Chair of Pharmaceutics, School of Pharmacy, University College Cork, Ireland |
The symposium is organized on behalf of the graduate programme in pharmaceutical sciences, Drug Research Academy, by Professor Anette Müllertz and Professor Thomas Rades, Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen.
The symposium is free of charge and open for attendance by all interested parties. It is not necessary to pre-register.