Targeting the purine salvage pathway to improve outcome after brain injury

DRA lecture held by Professor Bruno Frenguelli, University of Warwick, United Kingdom

Bruno Frenguelli is Professor of Neuroscience with a background in neuropharmacology at the University of Warwick, United Kingdom. Among other roles, Prof. Frenguelli is Editor-in-Chief of the prestigious scientific journal Neuropharmacology.

His laboratory is especially interested in the effects of hypoxia and ischemia on synaptic transmission in the mammalian hippocampus. The hippocampus is a region of the brain critically involved in certain forms of learning and memory, but, paradoxically, is one of the most vulnerable regions of the brain to hypoxia/ischemia. There are many human clinical case studies in which cerebral ischemia is associated with profound anterograde amnesia and selective pathology of the hippocampus, in particular of CA1 pyramidal neurons.

To investigate the neuronal response to hypoxia/ischemia his lab uses a combination of electrophysiological, pharmacological, biochemical, biosensor and imaging techniques.

The lecture is organised on behalf of the graduate programme in pharmaceutical sciences, Drug Research Academy, by Associate Professor Blanca I. Aldana, Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen.

The DRA lecture is free of charge and open for attendance by all interested parties. It is not necessary to pre-register.

Map showing pavilion building in the University park

Map showing the location of rooms in the pavilion building